In vitro 3D Full-Thickness Skin-Equivalent Tissue Model Using Silk and Collagen Biomaterials
نویسندگان
چکیده
منابع مشابه
Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue
Despite huge efforts to decipher the anatomy, composition and function of the brain, it remains the least understood organ of the human body. To gain a deeper comprehension of the neural system scientists aim to simplistically reconstruct the tissue by assembling it in vitro from basic building blocks using a tissue engineering approach. Our group developed a tissue-engineered silk and collagen...
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Wounds and wound healing have always been one of the most important subjects that experimental researches were dedicated to. Simvastatin has been used for long as a common lipid lowering agent which was reported to have some pleiotropic effects such as antioxidation, anti-inflammation and immunomodulation. In this study we aimed to determine the effect of simvastatin on wound healing process in...
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Currently, human skin equivalents (HSEs) used for in vitro assays (e.g., for wound healing) make use of primary human skin cells. Limitations of primary keratinocytes and fibroblasts include availability of donor skin and donor variation. The use of physiologically relevant cell lines could solve these limitations. The aim was to develop a fully differentiated HSE constructed entirely from huma...
متن کاملEffectiveness of Woven Silk Dressing Materials on Full-skin Thickness Burn Wounds in Rat Model
PURPOSE This study evaluated woven silk textile for burn wound dressing materials in an animal model. METHODS Ten rats were used in this experiment. Full-thickness 2×2 cm burn wounds were created on the back of the rats under anesthesia. In the experimental group, the wounds were treated with three different dressing materials from woven silk textile. In the control group, natural healing wit...
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ژورنال
عنوان ژورنال: Macromolecular Bioscience
سال: 2012
ISSN: 1616-5187
DOI: 10.1002/mabi.201200262